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Welcome to the Siegel Lab!

“Better Living Through Chemistry”

Our goal is to live up to the classic tagline “Better Living Through Chemistry”, which we achieve through computational enzyme engineering. Enzymes are the primary means by which biology performs chemical transformations. Naturally evolved enzymes have been optimized over long periods of time to address challenges biological systems face in nature. However, modern society faces additional challenges in food, energy, and health. To address these challenges, novel catalysts are needed. The Siegel lab focuses on the use of computational, genetic, and chemical methods to design, build, and test enzyme catalysts tailored for today’s challenges.

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Interested in Undergrad Research? Click Here!

Are you seeking an undergrad research experience? Are you interested in computational modeling, protein design, biotechnology, and enzymes? Click here to learn more.

Undergraduate Research Opportunities

Our three primary objectives:

Discover novel biological tools to address modern challenges effecting the human condition across food, energy, and health systems.

Develop a molecular understanding of how enzymes are able to achieve unprecedented levels of catalytic proficiency and specificity.

Transform education (graduate, undergraduate, K-12, and the general public) through the use of modern technology and innovative teaching methods.

Keywords: Synthetic Biology, Computational Enzyme Design, High Throughput Screening, Enzymology, Kinetics and Binding, Protein Sequence-Structure-Function Relationships, Genome Mining, Technique and Methods Development, Education